IMMUNOLOGY 2010™ -- Career Services: Jobs Board!

IMMUNOLOGY 2010^TM JOBS BOARD

Pfizer
Cambridge, MA

Research Associates with experience in Inflammatory Bowel Disease

To schedule immediate interview email your CV and call:
Dr. Paresh Thakker
617-620-7259 (cell)
email: pthakker1@yahoo.com

Description:
Provide hands on scientific expertise within the Gastrointestinal (GI) Inflammation Group in Tissue Inflammation enabling them to investigate disease mechanisms, and evaluate targets in models of Crohn's Disease and Ulcerative Colitis.
- Provide scientific hands-on in vivo expertise within the GI Inflammation Group.
- Characterize and dissect out mechanisms of disease pathogenesis within an in vivo setting.
- Run ELISA, FACS, TLDA/RT-PCR and CBA/Luminex assays to fully characterize the GI inflammatory response.
- Analyze plot and present data to individuals and in group settings.

Requirements:
- At least a Bachelors Degree, preferably with a life science major.
- Good grasp of basic principles of immunology is a must.
- Strong in vivo skills in mice including direct intra-ileal injection and collection/isolation of lamina propria/Peyer's patch cells from mice desired.
- Characterization and assay experience with ELISA, FACS, TLDA/RT-PCR and/or CBA/Luminex.
- Significant hands-on in vivo expertise in mouse and/or rat disease models.
- Specific experience with Inflammatory Bowel Disease (IBD) including adoptive transfer models, chemical induced colitis and familiarity with genetic/spontaneous mutants is preferred.
POSTED: Immunology 2010 (AAI meeting)

Posted: 5/10/10

Postdoctoral Position in Immunology at UCLA

Positions are available for MD/PhD candidates, preferably US citizen/permanent residents, with interest in the immunopathogenesis of autoimmune diseases, with a focus on lupus, scleroderma and arthritis. Current projects include mechanisms and outcome of dendritic cell (DC) migration with a focus on skin-resident DCs; regulation of regulatory T cell subsets including gamma delta T cells, NKT cells, Treg cells and inhibitory CD8+ T cells; mechanisms of gender bias in autoimmune diseases; mechanisms of T cell anergy; and biomarkers of scleroderma lung and skin disease and lupus nephritis. Please send your CV and contact information of references to RRSingh@mednet.ucla.edu.

Posted: 5/7/10

Laboratory Technician

Medical Science & Computing, Inc. is searching for the Laboratory Technician to support the National Institutes of Health (NIH). This is a full-time opportunity with MSC, Inc., and it is on-site at NIH in Bethesda/Rockville, MD.

The candidates will screen and evaluate malaria vaccine candidates and investigate the pathogenesis of Plasmodium falciparum malaria.

Duties and Responsibilities
1. Planning, designing, conducting, and troubleshooting highly technical and complex research experiments.
2. Developing novel techniques as well as employing established technologies which may include, but are not limited to: PCR amplification, design of synthetic genes, gene cloning, protein expression and analysis, DNA ligation, bacterial and yeast transformations, microbial cell culture and basic manipulations, gel electrophoresis, DNA analysis, DNA isolation, DNA purification, DNA/gene sequencing (including SNP analysis), DNA gel purification, RNA sequencing, isolation and analysis, recombinant protein expression, purification and analysis, western blots, PAGE, column chromatography immunoprecipitation, manipulation of radioactive isotopes, phage display, ELISA, immunofluorescence assays, IFA microscopy etc.
3. Documenting and disseminating findings, methods, and procedures, including any modifications employed, specimens and materials involved, and results of experiments.
4. Interpreting, evaluating, and discussing the results of each experiment as part of the planning process for subsequent studies.
5. Participating in the analysis and interpretation of data and preparing summaries of laboratory findings to be used in reports and papers to be presented at scientific meetings and/or publication in scientific journals.
6. Calibrating, operating, and maintaining a variety of laboratory instruments used to perform tests, analyses, and other laboratory procedures which may include, but are not limited to: spectrophotometers, PCR thermocyclers, microcentrifuges, electrophorators, hybridization ovens, autoclaves, ultracentrifuges, radioactive counters, light/tissue culture microscopes, imaging systems, DNA sequencers, high voltage electrophoresis apparatus, gel chromatography equipment, balances, Bioanalyzer, incubators, waterbaths etc.
7. Searching scientific literature for new methods and procedures that may be considered for application or modification to selected experiments; selecting the appropriate methodology and procedures to meet the experimental objectives; maintaining accurate, daily records of experiments and results in pen in bound laboratory notebooks; making minor modifications or adaptations to established methods, procedures, and/or techniques to solve problems in the work.
8. Reviewing and researching the proper handling and methods of utilization for different biological and chemical materials in regular use in the laboratory;
9. Interacting and/or collaborating with scientists from other organizations or institutions involved in similar or related research projects.
10. Performing other duties as assigned by the supervisor, such as monitoring chemical and radiological hazards, conducting and reporting operational radiation surveys, etc.

Position Requirements

B.S. degree in biological sciences with a minimum of four years related experience.

Experience in gene expression profiling technologies such as microarray, quantitative real-time PCR, and second generation sequencing as well as immunological assays such as ELISA is required.

Experience with animals, including IACUC certification is desirable.

Candidate must possess sound practical knowledge of computer-based tools for sequence, genome and protein analysis. Will be required to perform computer analysis of data and use computer software or program novel code to prepare data for publication.

Please respond with resume and cover letter to Margaret Hishmeh at careers@mscweb.com

Posted: 5/6/10

Immunology Research Scientist

Medical Science & Computing, Inc. is searching for the Immunology Research Scientist to support the National Institutes of Health (NIH). This is a full-time opportunity with MSC, Inc., and it is on-site at NIH in Bethesda/Rockville, MD.

Duties and Responsibilities
- The position requires an individual with experience developing and standardizing laboratory techniques to measure immune responses of animals and humans.
- The research scientist will introduce new equipment or new technologies to facilitate high-throughput assays.
- He/she will explore immunostimulants and strategies for activating innate immune responses to malarial antigens in order to enhance adaptive immune responses.
- The research scientist will characterize and compare cellular and humoral immune responses to specific malarial antigens in naïve U.S. subjects and in malaria-infected individuals in Africa, especially among vulnerable populations such as children and pregnant women.
- The research scientist will use the assay development knowledge described above to create novel techniques, formally validate and standardize these techniques, and create standard operating procedures (SOPs).
- The research scientist will train staff on these SOPs and will ensure that documentation practices adhere closely to GLP and GCP standards, including responsibility for documentation management, deviation reporting and auditing. This will include training plans, instructional documents, forms, competency assessments, evaluations and certifications consistent with a GLP framework.
- The research scientist will also be responsible for laboratory safety, materials and study sample management.

Position Requirements

- The person who will successfully fill this position will have a deep interest in developing GLP standard immunology assays, ideally with several years experience in an industry setting.
- They will hold a Ph.D. or an M.D. with scientific training in a relevant field, such as immunology, infectious disease, parasitology, vaccinology, or others. Experience in malaria immunology, vaccine development and evaluation is a plus.
- Successful candidate will require in-depth understanding of the mechanisms of innate and adaptive immune responses and possible ways of increasing responses to vaccines; capacity of leading, inspiring, and supervising a group of talented technical staff for assay performance, development, and standardization.
- Hands-on experience with cellular assays is required.
- Scientist will have experience in human clinical trials and GCP, GLP regulated environments. Familiarity with CLIA and CAAP clinical safety laboratories would be advantageous.
- Ideal candidate should have experience with project management in a fast-paced, deadline-driven environment, with excellent communication and interpersonal skills.
- The position will require substantial computer and software proficiency. Required Microsoft applications include Word, Excel, Powerpoint, Access, Visio, Project Manager, and SharePoint platforms.
- Experience in statistical analysis software such as SPSS, SAS, JMP, or other analysis and graphing programs is desired.
- Experience and competency managing LIMS would be advantageous.
- The successful candidate must have comfort and ability to investigate and learn new equipment software interfaces and analysis programs used for scientific research and temperature monitoring.

Please respond with resume and cover letter to Margaret Hishmeh at careers@mscweb.com

Posted: 5/6/10

Product and Regulatory Affairs and Compliance Manager

Medical Science & Computing, Inc. is searching for the Product and Regulatory Affairs and Compliance Manager to support the National Institutes of Health (NIH). This is a full-time opportunity with MSC, Inc., and it is on-site at NIH in Bethesda/Rockville, MD.

Duties and Responsibilities
The Product and Regulatory Affairs and Compliance Manager (PRACM) is responsible for assisting with the management and regulatory compliance of malaria vaccine development initiatives, which will include malaria vaccine candidates for Phase 1 and 2 trials as well as experimental malaria infection studies involving human subjects. The PRACM will have responsibilities for regulatory documentation and coordination of production, quality control, formulation and other components of the vaccine development process. The PRACM will also work with and help coordinate contractors and other external contributors to execute multiple, concurrent experimental infection studies and malaria vaccine initiatives.

The PRACM will play a role in the coordination, from a QA perspective, of a series of steps performed by the various experimental infection and vaccine associated units. These steps will typically not involve participation in generating data or other laboratory work, but will involve data analysis and GLP standard document review and preparation. These steps and other responsibilities of the PRACM in order of significance to the position include:
- Preparation of IND and other regulatory documents
- Pre-clinical toxicology studies
- Review of the data from protocols, procedures and assays conducted by staff
- Production of a series of laboratory protocols for each product
- Development and implementation of QC procedures for assaying purity, integrity, stability and potency of the bulk antigen and formulated products
- Production of clinical grade formulated vaccine
- Conduct of Phase 1 and 2 clinical trials
- Detailed immunogenicity studies to determine promising formulations and doses for vaccine trials
- GMP production of the bulk antigen
- Development of a purification process for producing clinical grade antigen
- Development of expression systems capable of producing sufficient clinical grade material for clinical trials
- Collection and organization of data generated by technology units, published literature, or other reports that are relevant to the projects
- Identification of potential technical gaps in development pathway, initiation of action to fill the gaps
- Logical division of projects into subtasks with detailed time lines; milestones for determining progression of these projects from one stage to another
- Monitoring the progress of tasks and initiation of early remedial action when agreed timelines are not likely to be achieved
- Participation in planning in response to specific issues facing projects, such as the impact new discoveries made by the technology units (or elsewhere) might have on projects
- Contribution to design and development of assays, trouble-shooting technical issues, and reviewing reports for product characterization

Position Requirements

- Masters Degree or PhD in biology, microbiology, chemistry or biochemistry
- Minimum 3 years regulatory affairs and compliance experience in pharmaceutical or biotechnology industries or related research and development organizations
- Experience with FDA vaccine approval process, particularly IND preparation and submission
- Experience with project/program management, preferably in pharmaceutical or biotechnology industries or related research and development organizations Using tools such as MS Project
- Knowledge of GLP, GMP and GCP
- Experience preparing laboratory protocols and regulatory documents.
- Experience in evaluating processes for compliance with procedures and regulatory requirements
- Demonstrated organizational skills are essential, as well as, strong written and oral communication skills

Please respond with resume and cover letter to Margaret Hishmeh at careers@mscweb.com

Posted: 5/6/10

Who we are
At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity, and on seeing each other's differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing – and is seeking people who have the same goals for themselves.

The following opportunity exists in our Nutley, NJ location:

ASSOC PRNCPL SCI - Translational Biology

Responsibilities:
We are seeking an independent and experienced scientist for our translational biology group in the Inflammation Discovery Area. This individual will be responsible for the development and execution of cellular and molecular immunology studies designed to support our comprehensive translational pharmacodynamic activity and biomarker assessments. Responsibilities will include establishing and implementing novel cell-based assays and developing novel technology platforms. This individual will be expected to collect and analyze data in a timely manner, maintain laboratory notebooks, make presentations in group and departmental settings and write protocols and reports with limited direct supervision.

Requirements:
The successful candidate should have a Bachelor's degree with at least 5-10 years of experience or a Bachelor's and Master's degree with 3-5 years of experience and will have a track record of achievement in utilizing cell and molecular biology approaches to address innovative scientific hypotheses. Expertise in cell and tissue culture, cell function assays, cell purification/enrichment, multiplex analysis and ELISAs and cytology is highly desired.

Who you are
You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies and where a job title is not considered the final definition of who you are, but the starting point.

Job ID No.: 20500

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/6/10

R&D Scientist – Immunology

We are seeking a talented and highly motivated immunologist to join our new product development team.

The primary responsibilities of this position include but are not limited to: research, identify, and develop new products; initiate and maintain effective internal and external collaborations; plan and carry out experimental test regimes, analyze and interpret results. A Ph.D degree in biology and 2+ years of academic experience is required. The successful candidate is knowledgeable in cutting-edge life science technologies, especially in the fields of innate immunity and inflammation, with an excellent track record of scientific achievement as demonstrated by publications, proven scientific activities in creative thinking, data explanation, and problem solving. Excellent verbal and written communication skills are required. Industrial experience is a plus.

Requirements:

- A Ph.D. in Biology or related field + a minimum of 5 years of academic experience

- Industry experience

All qualified candidates must submit resume and apply online at http://www.biolegend.com/careers/

Posted: 5/5/10

Who we are: At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity, and on seeing each other’s differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing – and is seeking people who have the same goals for themselves. The following opportunity exists in our Nutley, NJ location:

Senior Principal Scientist - Quantitative Signal Transduction Cell Biologist

Responsibilities:

This position is to direct a group of scientists and research associates who devise, implement and perform cell based assays to support inflammation, drug discovery projects. In addition this individual will lead projects at the target assessment through lead optimization stages, represent basic research on early development teams, propose new projects and manage collaborations with outside investigators.

This individual will participate in running and developing new assays that assess the pharmacodynamic efficacy and mechanism of action of biologic and small molecule modulators of targets in our inflammation/autoimmunity portfolio. This person will interface with multiple drug discovery and translational research teams by providing data to support program needs such as mechanism of action assays and pharmacodynamic assays and expert advice as well. This person will have full scientific/technical responsibility for the achievement of broadly defined project and departmental goals. Additionally, this individual will establish and manage relationships with outside collaborators that provide additional capabilities not available with the organization.

Requirements:

The candidate must have a Ph.D in cell biology/signal transduction and at least seven years of post Ph.D experience. A strong background in signal transduction and target validation is required. Standard cell and molecular biology skills plus hands on experience with flow cytometry, reporter assays, high content imaging, ELISA assays, automation and 384 well formats (desired but not essential). Knowledge of kinase biology, gpcrs and/or ion channels as well as intracellular signaling in immune cells is required as is experience with establishing cell-based assays for use in drug discovery. Experience with the use of phoshoflow and other technologies for pathway mapping and mechanism of action studies is strongly preferred. In addition, previous experience in leading drug discovery projects is essential. Ability to evaluate and independently implement new technologies is essential. Strong problem solving skills and excellent written and verbal communication skills are also required. An established track record of successful drug discovery research experience is required. The applicant must have a solid publication record.

Who you are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies, and where a job title is not considered the final definition of who you are, but the starting point.

Job ID No.: 15418

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/5/10

Senior Research Leader

Responsibilities:

An opening is available in the inflammation discovery department for a dynamic and motivated senior research leader/associate director with extensive knowledge of both biologics and small molecule-based approaches to drug targeting. The applicant will utilize and build extensive immunology expertise to help identify and validate drug targets for autoimmune disorders including rheumatoid arthritis, systemic lupus erythematosis and inflammatory bowel disease. He/she will effectively direct research efforts to accelerate decision making and facilitate the preclinical development of drug candidates. The candidate will design and implement pharmacodynamic models based on appropriate immunopharmacology and mechanism of action to establish PK/PD/ and preclinical efficacy model relationships to enable human dose selection.

The applicant will interface with Discovery, Translational Research and Early Clinical Development teams to develop an end-to-end strategy as well as personalized health care/biomarker approach to drug development in order to enable a rapid transition of small molecules and biologics from lead optimization through clinical candidacy into early clinical trials.

Requirements:

This position requires a PhD or MD and an in-depth knowledge of chronic autoimmune/inflammatory diseases, immunobiology and/or cell signaling pathways. The candidate must have a strong leadership record spanning at least 10 years. The applicant must have effective management and mentoring skills. The ideal candidate will have a entrepreneurial spirit with track record of innovation and the ability to positively motivate others. Robust communication, organizational and interpersonal skills are required to manage projects and team members in a matrix environment. The applicant must have a proven drug discovery track record of advancing drug candidates from discovery into clinical development.

Who you are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies and where a job title is not considered the final definition of who you are, but the starting point.

Job ID No.: 20828

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/5/10

Post-Doc Fellow

Responsibilities:

An industry-funded postdoctoral research position is available in the Inflammation Discovery and Translational Area at Hoffmann-La Roche, Nutley, NJ. This joint Industry-Academia postdoctoral opportunity consists of a close collaboration with Prof. Linda Wicker in the Department of Genetics at Cambridge Institute for Medical Research, University of Cambridge, UK. The postdoctoral position will be based in Nutley, but the candidate will have the possibility to travel to University of Cambridge and other Roche affiliated sites (e.g. Glycart, Zurich) to conduct specific studies.

The scope of research focuses on the strategic thinking, generation and in vitro and in vivo characterization of engineered multispecific (e.g. bi-specific, tri-specific) antibodies and fusion proteins for targeting regulatory T cells to dampen inflammatory responses as potential treatment for autoimmune diseases.

The candidate's responsibilities consist of delineating the underlying biology of regulatory T cells to better understand the role of cytokines and specific costimulatory and other surface molecules in regulatory T cell activation, function and homeostasis. The candidate will develop cell-based and whole blood assays to characterize the efficacy of the engineered multispecific biologics in vitro as well as pharmacodynamic animal models for target modulation and in vivo testing. Active participation to distinguished immunology meetings and publications in high level peer reviewed journals are anticipated.

Requirements:

We are seeking candidates with a PhD in Immunology with a strong immunology background and excellent written and verbal skills in English. The candidate should have experience with animal work (mice) and be proficient with immunology and cellular and molecular techniques including >8-color flow cytometry (phosphoflow, intracellular staining, CFSE, etc.), cell isolation, co-culture suppression assay, immunoassays, ELISPOT, Luminex and mesoscale MSD technologies, TaqMan real time-PCR, adoptive cell transfer models and disease models of autoimmunity.

Who you are

Job ID No.: 20830

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/5/10

Post-Doc Fellowship, Respiratory Biomarkers

Responsibilities:

This position is a post-doctoral fellowship in the Biomarkers group within the early development organization in the Inflammation DTA. The post-doctoral scientist will work closely with the Biomarker Expert (leader of Biomarkers group), members of the Biomarkers group and members of the Discovery group. The Biomarker Expert has extensive experience in the identification of RNA and protein markers in autoimmune diseases using different assay platforms and utilizing bioinformatics methods to relate these data to clinical outcomes. The proposed post-doctoral research is focused on better understanding of the disease pathophysiology and the role of specific pathways in well-defined asthma and Chronic Obstructive Pulmonary Disease (COPD) patient populations. Biosamples from matrices closely associated with the target organ will be obtained from these patients and be evaluated for specific protein and mRNA markers.

These collaborations are currently being developed with key investigators in the respiratory field. These collaborations will support a personalized health care approach for the development of therapies within asthma and COPD. The candidate will develop multiplex protein assays, as well as other multiplex platforms, for detection of specific proteins in sputum, BAL and lining fluids from asthma, COPD patients and normal healthy donors. The candidate will also learn to evaluate mRNA levels in these matrices using a novel technique developed by an external collaborator. The candidate will also develop an understanding around bioinformatic techniques and learn about CT as a semi-quantitative methodology for measuring changes in lung structure in asthma and COPD. The anticipation is that the research conducted will result in multiple publications written by the post-doctoral scientist in association with the Biomarker Expert

Requirements:

The qualified candidate will have a PhD in Immunology, preferably with experience in multiplex protein assay methods, molecular biology techniques and bioinformatics techniques and an interest in the cellular immunological aspects of asthma disease processes. The post-doctoral candidate will need to become a technical expert in measurement of proteins in different matrices using multiplex protein assay methods as well as transcriptomics. The post-doctoral scientist should also have skills in complex problem solving, critical data analysis and interpretation and good presentation skills.

Who you are

Job ID No.: 20522

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/5/10

Post-doctoral positions

Immunological mechanisms of protection in human/animal vaccine development

Center for Vaccine Development (CVD), Univ. Maryland

Available Immediately

Join a multidisciplinary group of basic and translational researchers working to uncover the mechanisms underlying protective innate, cellular and antibody immune responses to a variety of microorganisms providing the rationale for new vaccine development and manipulation of host-pathogen interactions for disease prevention. Exciting new studies include exploration of the mechanisms operative in the generation of mucosal immunity in the gut microenvironment in humans and its relationship to the microbiota. These investigations are part of a recently awarded prestigious NIAID-funded Cooperative Center for Translational Research in Human Immunology and Biodefense (Sztein, P.I.). Studies include working with specimens obtained from children, adults and elderly subjects immunized with genetically engineered S. Typhi and Shigella vaccine candidates, as well as with malaria, hepatitis B, influenza and tularemia candidate vaccines.

State-of-the-art immunological and molecular biology techniques (e.g., 14-color flow cytometry, gene expression microarrays, etc) are used to study antigen presentation, MHC-restriction, cloning and characterization of cytotoxic and helper T cells, identification of protective epitopes, role of dendritic and regulatory T cells and manipulation of cytokine production to elucidate their role in the induction of innate, systemic and mucosal immune responses to vaccination and mechanisms of immunosenescence.

The CVD offers a unique environment to study cellular and molecular determinants of protection to infectious diseases in humans. The CVD, largely supported by NIH funding and private foundations, has earned an international reputation for genetically engineering and testing vaccines against typhoid, shigella, cholera and malaria. Based at the School of Medicine, University of Maryland, Baltimore, the CVD was established in the mid-1970s as one of the first facilities to evaluate vaccines in community volunteers. It is one of only a handful of vaccine centers in the world engaged in the full range of vaccinology - from basic science through vaccine development, immunological studies, clinical evaluation and field studies.

The successful candidate should have a Ph.D. in Microbiology/Immunology or M.D. degree, experience in the study of immunological mechanisms, a strong publication track record, be highly motivated, have effective written and oral communication skills and hold a valid VISA to work in the US. Experience in flow cytometry and other CMI techniques, as well as molecular biology, microarray and/or tetramer technologies is highly desirable. Please send curriculum vitae, a brief outline of relevant research experience and interests and the names of three references via e-mail to Marcelo B. Sztein M.D., Professor of Pediatrics; Leader, CVD Immunology Group; Chief, Cellular Immunology Section and Flow Cytometry Core Laboratory; CVD; University of Maryland at msztein@medicine.umaryland.edu.

I will be available to meet with interested candidates at this AAI meeting. Please leave me a note in the bulletin board at the AAI booth in the Exhibit Hall or call me at (443) 538-1734.

Posted: 5/4/10

Postdoctoral Fellow

MHC class I- and class II-restricted antigen processing

T cell responses and memory

Viral immunity and pathogenesis

NIH funded position immediately available in the laboratory of Laurence Eisenlohr, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA.

We have a variety of interests with our major focus being the cell biology of MHC class I- and class II-restricted antigen processing and presentation. Our antigen systems are mainly clinically relevant viruses including influenza, vaccinia, ectromelia (the mouse poxvirus), and adenovirus. From this base we have several related projects including T cell responses and memory, cancer immunity, T cell tolerance, and vaccine development.

Thomas Jefferson University is located in Center City Philadelphia, adjacent to the historic, theater and restaurant districts. It is convenient to several modes of transportation that extend well beyond the city limits. Benefits are excellent.

Requirements:

- Enthusiasm for discovery

- Independent thinking

- PhD in Immunology or Microbiology from a well-respected institution (MD will be considered)

- Publications in peer reviewed journals

- Experience with in vitro immune activation assays, mouse models, flow cytometry and biochemical techniques

- Excellent written and spoken English

Desirables:

- Experience with viruses – expansion and characterization

- Interest in academic career

- Willingness to train others

I can be available for a meeting at AAI Immunology 2010. Please send a CV, research interest statement, and contact information for three references to:

Laurence C. Eisenlohr, VMD, Ph.D.

Professor, Microbiology and Immunology

Thomas Jefferson University

BLSB Room 730

233 South 10^th Street

Philadelphia, PA 19107

Laurence.Eisenlohr@jefferson.edu

Posted: 5/4/10

Post-Doctoral Position in Molecular and Cellular Immunology

There is an immediate opening for a highly motivated and passionate PhD, MD/PhD or MD to investigate the Immunobiology of Lyme Disease initiated by Borrelia burgdorferi infection in the human setting. The work will involve molecular and cellular characterization of the T cells mobilized during infection including their antigen recognition properties and effector/regulatory functions. Prior training experience in molecular and cellular immunology would be an asset. The individual will have access to state of the art core facilities and be part of a team using systems biology based approaches to this novel and complex disease.

Please send, via email or mail, current complete c.v. and names/contact information of three references to: Mark J. Soloski Ph.D., Division of Rheumatology, Johns Hopkins School of Medicine, 5200 Eastern Avenue, Mason Lord Building, Center Tower, Suite 6000, Rm 677, Baltimore, MD 21224 (mski@jhmi.edu). If you are at AAI 2010 in Baltimore perhaps we can meet.

Posted: 5/4/10

Immunology Science Editors

Scientific Copyeditor for Contract Assignments

Who we are: Immunology Science Editors (www.immunologyeditors.com) is the only scientific editing company to focus solely on the writing needs of Immunologists. We provide meticulous English-language editing for all types of scientific documents within the broad field of Immunology.

Scientific Copyeditors wanted: We are seeking 2-3 trained Immunologists to perform part-time scientific editing of research documents. Successful applicants will work from home on a per-assignment basis to perform initial editing of Microsoft Word documents. We are interested in assembling a team of primary editors who have complementary research experiences in the broad field of Immunology.

Requirements:

Applicants must have excellent written and oral English skills, and must possess:

· A Doctorate degree in Immunology or related field

· 4-5 years of research experience in any area of Immunology

· Excellent writing and editing skills with correct grammar usage

· Ability to work independently and reliably under tight deadlines

· Ownership of home computer or laptop (PC or Macintosh) running Vista or OSX 10.5, respectively.

If interested, please email your CV, cover letter, and writing sample to:

Dr. Barbi Judd, Ph.D.

Co-Owner and Managing Editor

Immunology Science Editors

editors@immunologyeditors.com

For more information, visit us at AAI 2010 booth # 1102.

Posted: 5/3/10

At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity, and on seeing each other’s differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing – and is seeking people who have the same goals for themselves. The following opportunity exists in our Nutley, NJ location:

In Vivo Rheumatologist (Principal Scientist)

Responsibilities:

We are seeking an innovative and highly collaborative scientist to play a key role in our in vivo rheumatology group within the Inflammation Disease Biology Area. The successful candidate with have expertise in the design and execution of in vivo models of inflammatory joint disease and a thorough appreciation for the intricacies of inflammatory pathways as they apply to the pathophysiology of rheumatic diseases. This researcher will serve on small molecule and biologics project teams and will be expected to identify novel targets, publish scientific findings and present at scientific conferences.

Requirements:

The successful candidate will possess a Ph.D. and 3-5 years of experience in the development and implementation of in vivo models of inflammatory diseases. A strong publication record or evidence for having made innovative contributions to target validation, biomarker identification and program progression is essential. A comprehensive understanding of state-of-the-art immunobiology concepts and principles is a must, as is evidence for strong communication and problem-solving skills. Experience with a variety of technology platforms applicable to the study of inflammatory diseases, including flow cytometry and imaging, is preferred.

Who you are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies and where a job title is not considered the final definition of who you are, but the starting point.

Job ID No.: 15725

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/3/10

Principal Scientist - Flow Cytometry

Responsibilities:

We are seeking a highly motivated and collaborative flow cytometry specialist to join the Translational Biology group in Inflammation Discovery. Essential responsibilities will include designing and conducting flow cytometry-based studies to facilitate target validation, mechanism of action and biomarker discovery and confirmation studies. This individual will devote the majority of his/her time to benchwork and will have ample opportunity to collaborate with experienced scientists from Discovery, Early Development and Molecular Medicine. Additional responsibilities will involve the maintenance of several FACS instruments. The individual in this role will be expected to contribute to project team discussions, present scientific findings and publish their work in scientific journals. A strong history of scientific and technological innovation, evidence of robust problem-solving skills and an ability to thrive in a fast-paced, matrixed environment are required.

Requirements:

The successful candidate will possess a Ph.D. and 3-5 years of post-doctoral experience in the development and execution of a variety of flow cytometry-based assays, including data analysis, management and presentation. A thorough understanding of the technical aspects of flow cytometry and of state-of-the-art immunobiology principles is a must. A demonstrated ability to deliver scientific innovation and impact as an individual contributor or as part of a team is required. Prior experience with imaging cytometry and technologies, immunological techniques and molecular biology is desirable, as is evidence for strong oral and written communication skills.

Who you are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies and where a job title is not considered the final definition of who you are, but the starting point.

Job ID No.: 17930

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/3/10

Senior Principal Scientist - Quantitative Signal Transduction Cell Biologist

Responsibilities:

This position will direct a group of Research Associates and Scientists who perform cell based assays to support rheumatology drug discovery projects. In addition this individual will lead projects at the target assessment through lead optimization stages, propose new projects and manage collaborations with outside investigators.

This incumbent will participate in running and developing new assays that assess the pharmacodynamic efficacy and mechanism of action of biologic and small molecule modulators of targets in our rhematology portfolio. This person will interface with multiple drug discovery teams by providing data to support program needs such as mechanism of action assays and pharmacodynamic assays and expert advice as well. This person will have full scientific/technical responsibility for the achievement of broadly defined project and departmental goals. Additionally, this individual will establish and manage relationships with outside collaborators that provide additional capabilities not available with the organization.

Requirements:

The candidate must have a Ph.D in cell and molecular biology/signal transduction and at least seven years of post Ph.D experience. A strong background in signal transduction and target validation is required. Standard cell and molecular biology skills plus hands on experience with flow cytometry, reporter assays, high content imaging, ELISA assays, automation and 384 well formats (desired but not essential). Knowledge of kinase biology as well as intracellular signaling in immune cells is required as is experience with establishing cell-based assays for use in drug discovery. Experience with the use of phoshoflow and other technologies for pathway mapping and mechanism of action studies is strongly preferred. In addition, previous experience in leading drug discovery projects is essential. Ability to evaluate and independently implement new technologies is essential. Strong problem solving skills and excellent written and verbal communication skills are also required. An established track record of successful drug discovery research experience is required.

Who you are

Job ID No.: 15418

The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com.

Roche is an Equal Opportunity Employer fully committed to workplace diversity.

Posted: 5/3/10

POSTDOCTORAL POSITION in Parasite Immunology/Vaccine Development/Cancer Immunotherapy

NIH-funded position is currently available at the Los Angeles Biomedical Research Institute (LA BioMed) at UCLA-Harbor Medical Center in Torrance, CA (Los Angeles South Bay area).

The Craft Laboratory studies models of immunotherapy, including melanoma and leishmaniasis, with a focus on clinical translation. Current areas of interest in the laboratory include mechanisms of Leishmania resistance, novel cell-mediated vaccine development, and TLR-mediated potentiation of CD8+ T cell vaccines.

Candidates should have a PhD or MD degree, a demonstrated record of scientific accomplishment, and a solid background in immunology, preferably tumor immunology or parasitology. Familiarity with tissue culture techniques, molecular biology, flow cytometry, and in vivo mouse models of vaccination and disease, is also desirable. Candidates should be able to communicate well and work independently.

Lab:

Noah Craft, M.D., Ph.D.
Los Angeles Biomedical Research Institute
Department of Medicine, Division of Dermatology
http://www.dermatology.labiomed.org/page2.php?mytext=users/drcraft.txt

Qualified candidates should email a CV and a brief statement of research interests, along with contact information of three references, to:

Kevin W. Bruhn, Ph.D.
kbruhn@labiomed.org

Posted: 5/3/10

Group Head - I and I T-Cell Biology - Senior Principal Scientist / Associate Research Fellow - 936971

Lead the T cell Biology group and providing scientific and managerial leadership in the field of adaptive immunity with emphasis on T cell pathways and oversee the discovery of novel biopharmaceutical drug candidates for the control of autoimmune and inflammatory diseases.

The overall responsibility will be to provide strong scientific and managerial leadership in the discovery and development of drug candidates targeting pathogenic adaptive immune pathways with emphasis on T cell mediated responses. The successful candidate will lead a group of research assistants and PhD scientists to ensure high quality results and timely drug discovery project advancement; will oversee the development, optimization and characterization of cell-based assays for T cell-targeted biopharmaceuticals; will design and implement strategies for the identification and characterization of novel pathways targeting immune cells with emphasis on T cells; will actively participate in and/or lead T cell related drug discovery project teams; will participate in and/or lead the evaluation of T cell-targeted drug discovery technologies; will manage global Pfizer and external collaborations with academics and other Biotech Companies on the implementation of new technologies and on the development of biopharmaceuticals targeting adaptive immune pathways. Also, a key responsibility of this leadership position is the management of the FACS group, which is responsible for the flawless execution of the flow cytometry technologies, including cell sorting, for the entire Inflammation and Immunology Department. They will fruther need to maintain strong external and internal scientific credibility through participation and presentations at major external scientific meetings and through publication of internal research and academic collaborations.

A strong scientific background in Immunology and T cell Immunity is a requirement. Proven skills and experience in overseeing a variety of immunological assays, including T cell functional assays, FACS, ELISA, CBA/LUMINEX/MSD technologies.

- A PhD is required. A doctorate in Cellular Immunology is preferred.

- A minimum of 8 years of relevant post doctoral experience, in the academia and/or industry.

- Demonstrated experience in managing research assistants and PhD scientists.

- Proficiency in overseeing the design and running of cell-based assays for the development of immunomodulatory therapies.

- Demonstrated skills in scientific collaborations and good publication record in peer reviewed journals.

- Strong external and internal scientific credibility.

- A proven history of management skills (project and people).

- Effective communication skills.

Pfizer Inc: Working together for a healthier world

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide. If you are interested and meet the listed requirements, please go to www.Pfizer.com/Careers, search for the Job ID and apply on-line.

Posted: 5/3/10

Associate Research Scientist/Post Doctoral Fellow

Immunobiology and Cancer Research Program

OMRF: Discoveries That Make A Difference

Postdoctoral position available immediately to pursue collaborative studies on cell development and lineage decisions. Successful candidates for this training position should have prior tissue culture experience and a strong background in molecular biology, developmental biology, and/or immunology, as well as aspirations for an independent scientific career. Preference will be given to candidates with documented success in research, such as recent first author publications. Additional information about the Immunobiology and Cancer Program can be found at www.omrf.org/OMRF/Research/14/Welcome.asp.

OMRF (www.omrf.org) is highly ranked amongst the biomedical research institutions within the United States of America, and internationally. OMRF is independent, not-for-profit, and is adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. OMRF investigators enjoy close scientific interactions with OUHSC faculty and participate in OUHSC graduate programs. Oklahoma City is quickly becoming a desirable city to live in. It's attributes include an open-atmosphere downtown area, world-renowned arts and heritage museums, performing arts centers, multi-cultural restaurants, convention centers, botanical gardens, a science center, and an exceptional zoo, to name a few.

Contact information: Please send a CV, statement of research interests and names of three references to: Carol F. Webb, Ph.D., E-mail: Carol-Webb@omrf.org, FAX: (405) 271-7128.

OMRF offers competitive salaries, comprehensive benefits and a collegial work environment.

EOE/AA

Posted: 5/3/10

Process Development Scientist I/II, Protein Chemistry
BioLegend

We are searching for a dynamic, intelligent scientist to support the VP of Operations that will be able to lead and supervise the department, in addition to the following responsibilities:

• Independently, design and execute experiments for process development, optimization, scale-up, technology transfer, and validation.

• Effectively troubleshoot and provide technical services for manufacturing processes.

• Carry out, input technical direction and execute custom projects.

• Influences the course of projects, scientific methods and/or company's technical direction

• Proactively identifies complex obstacles to progress; recommends and implements solutions using a diverse set of resources; solves problems in creative and effective ways; challenges current processes and recommends novel approaches

• Mentors Research Associates and lower level Scientists

Requirements:

• Ph.D. in life science with thesis, publication(s) and minimum two years of relevant experience

• Possess high level protein chemistry skills, including purification, labeling and fragmentation, with demonstrated application and creativity

• Demonstrated ability to successfully direct and execute multiple projects simultaneously and ability to meet project deadlines

• Excellent communication and ability to work in a team setting

All qualified candidates must apply and submit resumes on the Careers page of our website: http://www.biolegend.com/careers_frame/

Posted: 4/28/10

Scientist/Senior Scientist, Infectious Disease

Theraclone Sciences is an early stage research company located in Seattle, WA (www.theraclone-sciences.com). We discover human monoclonal antibodies for therapeutic or vaccine development using the state-of-the-art I-STAR technology (Walker LM et al, 2009, Science, 326:285-9). Our product portfolio targets infectious and inflammatory diseases of significant clinical impact.

We are seeking a Ph.D. scientist to design and execute research in isolating and characterizing human antibodies naturally elicited against viral and/or bacterial pathogens. You will contribute in major project teams and will have opportunities to identify and lead discovery projects. You should have extensive research experience in virology and/or microbiology with track record of most of the following:

• Demonstrated ability to manage and deliver results in discovery projects.
• Hands-on expertise with in vitro virology and/or microbiology laboratory techniques.
• Extensive infection inhibition studies with neutralizing antibodies and/or antivirals using various neutralization assay methods.
• Experience with methods related to innate immunity such as virolysis, opsonophagocytosis, ADCC and CDC.
• Experience with antibody and peptide-based assays or other advanced technologies to characterize therapeutic candidates.
• Experience with automated lab equipments to develop and execute medium-to-high throughput low-volume assays.
• Experience in designing in vivo efficacy studies using animal models is preferred.
• Previous employment in biotech industry is highly desirable.

Qualification Requirements:

• Ph.D. in virology, microbiology, or immunology with over 3 years of post-doctoral experience. Alternatively, M.Sc. in similar disciplines with over 10 years of post-master research experience.
• Good track record of publications in relevant research areas.
• Broad in-depth knowledge in areas of expertise to support experimental designs.
• Self-motivated, proactive and collaborative team member.
• Excellent in high-volume reporting in Excel workbooks, PowerPoint presentation and writing skills.

Theraclone offers a team-oriented, stimulating work environment. Competitive compensation, benefits and stock options are offered. Please mail, email or fax your resume with cover letter to:

Theraclone Sciences
Seattle Life Sciences Building
1124 Columbia Street, Suite 300
Seattle, WA 98104
email: careers@theraclone-sciences.com
Fax: 206.805.1699

Posted: 4/26/10

NIH-funded Postdoctoral Position in Mucosal/Viral Immunology

A post-doctoral research position is available immediately in the laboratory of Dr. Linda J. Saif of The Ohio State University for a recent PhD trained in mucosal/viral immunology. Training in virology is desired. Research focus is on mucosal immunity to human enteric viruses and mucosal viral vaccines (virus-like particles, etc) and immunomodulators (adjuvants, micronutrients, probiotics, etc) in a neonatal animal model for human disease. Our laboratory focuses on comprehensive studies of innate and adaptive T and B cell mucosal immune responses in neonates to enteric viral pathogens and vaccines. The immune correlates of protection are assessed by challenge studies using our unique neonatal germfree animal disease models.

Requirements:

-A recent Ph.D. in immunology or virology
-Relevant documented experience in immunology including immunoassays and flow cytometry
-Experience in mucosal immunology, virology, cell culture and animal handling desired
-Excellent written and oral communication skills in English and ability to collaborate within a research team

Please send resume, one page statement of laboratory skills, scientific accomplishments, interest, goals and contact information for 3 references via e-mail addressed to:

Dr. Linda J. Saif
Food Animal Health Research Program
OARDC/The Ohio State University
1680 Madison Ave.
Wooster, OH 44691
email: saif.2@osu.edu
web site: http://www.oardc.ohio-state.edu/lsaiflab/

Posted: 4/23/10

NIH-funded postdoctoral position is expected to be available at the University of Maryland School of Medicine starting July 1^st, 2010. Successful candidate will study molecular mechanisms of TLR signaling. The project involves identification of interfaces that mediate signal-dependent TLR adapter recruitment to understand better the architecture and mechanisms of assembly of TLR signaling complexes.

Requirements:

Recent PhD in Molecular and Cellular Biology, Biochemistry, or Immunology.
A peer-reviewed publication that demonstrates candidate’s proficiency in “wet-bench” cell signaling work.

Preference will be given to applicants with experience in screenings for inhibitors of cellular signaling, quantitative real-time PCR, Western analysis, fluorescence microscopy, or structural protein modeling. This position involves experiments with mice (~15% of time).

Please send CV, a brief statement of research interests, and names of two references to:

Vladimir Y. Toshchakov, Ph.D.
Department of Microbiology & Immunology
University of Maryland School of Medicine
685 W. Baltimore Street, HSF I, Suite 380
Baltimore, MD 21201
Phone: 410-706-4716
E-mail: vtoshchakov@som.umaryland.edu

Interested applicants who plan to attend IMMUNOLOGY 2010 are encouraged to contact me to arrange an interview during the Meeting.

Posted: 4/22/10

Autoimmune Mechanisms Group Leader - Senior Principal Scientist / Associate Research Fellow
Pfizer
Cambridge, MA (Boston)
Job ID 937003

Lead the Autoimmune Mechanisms group to identify the appropriate in vivo short term mechanistic models to support the development of novel therapeutics for autoimmune disease.
- Lead and supervise a team of scientists in an effort to develop the appropriate short-term models for novel therapeutic pathways for autoimmune diseases and to design the appropriate studies to understand the biology, and to assess efficacy, of promising therapeutic agents for autoimmune disease.
- Lead the group to generate publication-quality data related to autoimmune pathways and potential therapeutics that will change the lives of patients.

Requirements

- PhD in Immunology or a related field with a strong background in immunology and/or autoimmunity.
- At least 8 years of relevant postdoc research experience.
- Strong project and people management skills including experience leading a team of scientists in an industrial setting (pharmaceutical, biopharmaceutical, medical device).
- Animal modeling experience. Experience with non-human primate models and a knowledge of statistics as it relates to animal model development and compound testing is highly desirable.
- Experience with the ex vivo assays required to understand the biology of the disease, including FACs, ELISA, and RT-PCR.
- A record of peer-reviewed publications.
- Excellent interpersonal and communication skills including the ability to work with partner lines, external collaborations and academic labs.

If you are interested and meet the listed requirements, please go to www.Pfizer.com/Careers, search for the Job ID and apply on-line.

Contact

Cheryl Nickerson-Nutter, Ph.D
Director Inflammation Autoimmunity
617-665-5229

Posted: 4/21/10

Multiple Sclerosis Group Leader - Senior Principal Scientist / Associate Research Fellow
Pfizer
Cambridge, MA (Boston)
Job ID 937007

Lead the Multiple Sclerosis (MS) group to identify novel therapeutics for the treatment of MS.
- Develop, mentor and supervise a team of scientists (PhD and non-PhD) in an effort to understand the mechanisms of models of MS and how these mechanisms relate to human disease. This will include the design of the appropriate studies to understand the biology, and to assess the efficacy, of promising therapeutic agents.
- Develop, research and evaluate different transfer models and relapsing-remitting models to determine which model to use for a given target. This will include rat, guinea pig, and mouse models.
- Work closely with the Translational Medicine group to identify disease and target-associated biomarkers.
- Lead the group to generate publication-quality data related to MS target pathways and the development of potential therapeutics that will change the lives of patients.
- Shared budgeting responsibilities for research costs.

Requirements

- PhD in Immunology or a related field with a strong background in immunology and/or autoimmunity.
- At least 8 years of relevant postdoc research experience.
- Strong project and people management skills including experience leading a team of scientists in an industrial setting (pharmaceutical, biopharmaceutical, medical device).
- Animal modeling experience including handling, dosing, and monitoring rodent models of autoimmunity and expertise with ex vivo assays such as ELISA, RT-PCR, FACs.
- Experience with IND preparation is preferred.
- A record of peer-reviewed publications.
- Excellent interpersonal and communication skills including the ability to work with partner lines, external collaborations and academic labs.

If you are interested and meet the listed requirements, please go to www.Pfizer.com/Careers, search for the Job ID and apply on-line.

Contact

Cheryl Nickerson-Nutter, Ph.D
Director Inflammation Autoimmunity
617-665-5229

Posted: 4/21/10

Mayo Clinic Arizona
Senior Research Technologist II - 7823

The Research Technologist II independently executes experimental studies, after initial discussions with principal investigator, in support of lab goals, grant commitments, including independent sub-projects. In addition, the Research Technologist II designs and troubleshoots experiments and independently determines experimental progression; analyzes and aids in interpretation of data; authors and co-authors papers and presentations. The incumbent will train and give direction to residents/fellows/other lab personnel, review literature and customized techniques for lab applications and program needs, and independently develops new scientific protocols for research program. This position shares lab administration duties. The Research Technologist II must be innovative in the development of new instrumentation and methods and able to creatively apply and extract scientific literature to meet program needs.

Department: Research

Qualifications: Requires a bachelor's degree in biology, chemistry, or relevant sciences with several years of additional graduate study or course work in specialty area or a master's degree in biology, chemistry, or relevant sciences. Requires 8-10 years of research experience in a work or educational setting including design of independent research projects, data analysis, and interpretation. Requires a first authorship on a scientific publication and demonstration of presentation skills. Minimum of 5 years experience in a laboratory using the mouse as a model organism employing transgenic, cryopreservation, embryonic stem cell culture, or assisted reproductive technology preferred. Ability to perform microinjection and embryo transfer surgery - expertise in these techniques preferred. Receive scientific direction from the laboratory director but carry out day to day responsibilities independently. Good communication skills and an ability to work well with others as part of a team providing services and consultation to investigators. EEO/AA - M/F/D/V

Benefit Eligibility: Yes
Posting Begin Date: 04/13/2010
Posting End Date: Until Filled
Employment Type: Exempt
Hours/2-Weeks: 80
Schedule: Monday - Friday
Shift: Days - 8:00 am - 5:00 pm including some weekends and evenings
Building: Scottsdale Campus of Mayo Clinic, Samuel C. Johnson Research Building
Salary: Salaried - Education, experience, and tenure may be considered along with internal equity when job offers are extended.

To apply please visit this URL: http://www.applicationssite.org/recruit/servlet/com.lawson.ijob.QuickCandidate?vendor=300&ic=1

Once at this site, please go to the on line job form to apply using job number is 7823 , Senior Research Technologist II (transgenic specialist).

Posted: 4/20/10

Postdoctoral position in the targeting of Activation Induced Cytidine Deaminase (AID)

A postdoctoral position is available in the targeting of AID in the laboratory of Dr. Matthew D. Scharff at the Albert Einstein College of Medicine in New York City.

Requirements:

- Recent Ph.D or M.D. degree and peer reviewed publications
- Experience in molecular and cell biology
- An interest in DNA damage and repair
- Availability for an interview in Baltimore or New York

Please send a CV, a one page statement of laboratory skills, scientific accomplishments and interests and long term goals, and contact information for 3 references with e-mail addresses:

Dr. Matthew D. Scharff
Department of Cell Biology
Albert Einstein College of Medicine
1300 Morris Park Ave.
Bronx, NY 10461
e-mail: matthew.scharff@einstein.yu.edu

Posted: 4/15/10

Postdoctoral Positions: NK/NKT cells

Post-doctoral positions are available in the laboratory of Dr. Laurent Brossay at Brown University to study the role of NKT and NK cells during infection.

Requirements:

- Recent Ph.D. in Immunology or Virology
- Peer-reviewed publications
- Experience with Flow cytometry, biochemistry and animal handling (mice).
- Excellent verbal and written English skills.

Please send a CV, names and email addresses of three references and a one-page statement of research accomplishments and interests to:

Laurent Brossay, Ph.D.
Department of Molecular Microbiology & Immunology
Brown University
Providence, RI 02912
Email: Laurent_Brossay@brown.edu

Posted: 4/13/10

Stanford University School of Medicine

A postdoctoral position in immunology is available to study mechanisms of immune aging. We are interested in identifying signaling pathways in T cells that are defective with age and can be targeted to improve vaccine responses.

Candidates should have a recent Ph.D. degree in immunology, cell biology or related field and experience in cell signaling, molecular imaging technologies or gene profiling.

Interested applicants should send C.V., a short statement describing previous research experience, future goals and contact information of three referees to

Jorg Goronzy, M.D.
Department of Medicine
Division of Immunology & Rheumatology
CCSR Building
269 Campus Drive, Room 2215
Stanford, CA 94305-5166
jgoronzy@stanford.edu

Posted: 4/12/10

Postdoctoral position in Immunology at the National University of Singapore

A postdoctoral research position for a highly motivated researcher is available in the Grotenbreg laboratory (http://immunology.nus.edu.sg/grotenbreg_lab/home.html). Ongoing studies involve the development of novel tools and strategies for the investigation of cellular immune responses against clinically relevant pathogens in Asian populations, as well as studies that focus on the structural basis of how MHC-TCR affinity affects the development and functional properties of T cells.

Requirements:

1. A doctoral degree from a well-recognized institution and a strong background in immunology, structural biology or a related life science discipline.

2. Demonstrated creativity and technical independence with molecular, biochemical and/or immunological techniques.

3. The ability to take initiative and work independently, as well as a willingness to share knowledge and expertise within an international and interdisciplinary team.

4. A good publication record in recognized peer-reviewed journals will be highly advantageous.

Motivated individuals should send their application, up-to-date curriculum vitae and two letters of reference to the address below. An outstanding application would include a short description of what attracts you in our research.

Dr. Gijsbert Grotenbreg
National University of Singapore
Departments of Microbiology and Biological Sciences
mmunology Programme
28 Medical Drive
Centre for Life Sciences, #03-05
Singapore 117456
Email: gijsbert.grotenbreg@gmail.com

Salary and benefits will be commensurable to educational qualifications and working experience. To ensure full consideration, all application materials should be presented in a single submission. Applications will be reviewed starting March 01, 2010 and are accepted until the position is filled.

Posted: 4/5/10

Post-doctoral position at the University of Maryland, Baltimore, Dept. of Microbiology and Immunology, open to strong candidate with a Ph.D. in immunology, biochemistry, or mammalian genetics with molecular and genetics skills to study the role of TLRs and other pattern recognition receptors in susceptibility to infection. Position available immediately. Excellent verbal and written English skills required.

Please send a CV, a brief statement of interests and goals, a brief list of laboratory skills, and email addresses of two references (must be research supervisors or departmental faculty who are knowledgeable of your work) to the address below.

Stefanie N. Vogel, Ph.D.
Dept. of Microbiology and Immunology
University of Maryland, Baltimore
660 W. Redwood St., Suite 324
Baltimore, MD 21201 USA
410-706-4838
E-mail: svogel@som.umaryland.edu

Posted: 4/5/10

Postdoctoral Position: Viral Immunology and Immunotherapy

A postdoctoral position is available in Dr. Edward Usherwood's laboratory at Dartmouth Medical School to study the antiviral T cell response to persistent and acute virus infections. A unique opportunity is available to pursue in-depth research into effective immune therapies for persistent virus infection, and the optimization of memory responses. The laboratory focuses on understanding the biology of T cell memory in both acute and persistent virus infection systems in mice, with a focus on therapeutic intervention.

Requirements:
• A PhD in immunology or virology.
• Peer-reviewed publications in the field of immunology.
• Experience with T cell immunology, small animal handling, flow cytometry and molecular biology.
• Excellent spoken and written English
• Experience in viral systems is preferred.

Candidates should supply:
• Curriculum vitae
• Contact details for three referees, plus letters of reference.
• A description of how your experience fits with the requirements of the position.

Application materials should be emailed to EJU@Dartmouth.edu

Posted: 4/2/10

Postdoctoral Position: Innate Immune Mechanisms in Skin and Role in Chronic Inflammation

A postdoctoral research position is available in the laboratory of Dr. Liselotte E. Jensen at Temple University School of Medicine.

The successful candidate will be highly motivated to study innate immune mechanisms involving keratinocytes during chronic inflammation of the skin. Links to cardiovascular disease, asthma and arthritis may be explored. Experimental models will include in vitro assays, microarray screening, tissue culture and knockout/transgenic mice.

Information about the laboratory can be found at:
http://www.med.upenn.edu/pharm/faculty/jensen/jensen.html.

Requirements:
• A Ph.D. in Immunology, Cell Biology and/or Molecular Biology.
• Peer-reviewed publications in the field(s) of Immunology, Skin Physiology/Pathology and/or Signal Transduction.
• Extensive documented hands-on experience with molecular biology, biochemistry, immunology, histology, signal transduction, cell culture methods, animal handling (mice) and breeding.
• Excellent written and oral communication skills in English.

Candidates with additional experience with in vivo models of skin inflammation, working with clinical human samples and isolation of primary keratinocytes will receive priority evaluation.

Anticipated start date is July 1st, 2010; however, the position will remain open until a suitable candidate is identified.

Send cover letter with description of how your training background suits this position, CV and contact information for 3 references to:

Liselotte E. Jensen, Ph.D., Department of Pharmacology, University of Pennsylvania, 89 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6084.
E-mail: liselott@mail.med.upenn.edu

Posted: 4/1/10

Postdoctoral Position: Host-Pathogen Interactions

A postdoctoral research position is available in the laboratory of Dr. Liselotte E. Jensen at Temple University School of Medicine.

The highly motivated successful applicant will study the role of innate immune mechanisms during viral and bacterial infections of the skin. Experimental models will include in vitro assays, tissue culture and knockout/transgenic mouse models. The study aims to identify novel regulatory mechanisms of signal transduction.

Information about the laboratory can be found at:
http://www.med.upenn.edu/pharm/faculty/jensen/jensen.html.

Requirements:
• A Ph.D. in Immunology, Microbiology and/or Molecular Biology.
• Peer-reviewed publications in the field(s) of Immunology, Microbiology and/or Signal Transduction.
• Experience with molecular biology, biochemistry, immunology, histology, signal transduction, cell culture methods and animal handling (mice) and breeding.
• Excellent written and oral communication skills in English.

Additional experience with in vivo infection models and vaccine development is highly desirable.

Anticipated start date is July 1st, 2010; however, the position will remain open until a suitable candidate is identified.

Send cover letter with description of how your training background suits this position, CV and contact information for 3 references to:

Liselotte E. Jensen, Ph.D., Department of Pharmacology, University of Pennsylvania, 89 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6084.
E-mail: liselott@mail.med.upenn.edu

Posted: 3/30/10

NIH-NCI Fellowships: Signaling by the innate immune system in the inflammation associated with cancer development and progression

The laboratory studies signal transduction of the innate immune system. In vitro biochemical approaches are used to dissect signaling pathways in the innate immune system. Findings further studied using animal models of inflammation and cancer. As part of the NCI-Cancer and Inflammation Program, we are currently expanding translation of these projects into in vivo models of inflammation and carcinogenesis through the development of additional knockout and transgenic animals. Receptor systems under study include the Triggering Receptors Expressed in Myeloid Cells (TREM) and the Killer Immunoglobulin-like Receptors (KIR). Applicants must have a Ph.D. and/or MD and less than five years of postdoctoral experience. Signal transduction experience and/or experience studying myeloid cells is beneficial but not required. The successful candidate will be involved in the generation of transgenic and knockout models for these receptor systems so experience in this area is a plus. These National Institutes of Health (NIH) fellowship positions are fully funded and available immediately. The NCI-Frederick campus is located about 40 miles northwest of Washington DC in the foothills of the Blue Ridge Mountains. The campus houses NCI principal investigators and all of the resources to support state-of-the-art biomedical research including complete library services, publication services, clinical testing services, super computer facilities, and animal facilities including the NCI transgene and knockout cores. Candidates should submit a CV including contact information for 3 references and a brief description of how their background and education fit with our laboratory interests.

Daniel W. McVicar, Ph.D.
National Cancer Institute-Frederick
Building 560 Room 31-93
Frederick, MD 21702.
(301) 846-5163
Fax (301) 846-1673
mcvicard@mail.nih.gov

More information on the group can be found at http://ccr.cancer.gov/Staff/staff.asp?profileid=5707.

More information on the Cancer and Inflammation Program is at:
http://ccr.nci.nih.gov/labs/lab.asp?labid=790

Posted: 3/24/10

RESEARCH TEAM LEADER

HUMIGEN, L.L.C., the Institute for Genetic Immunology (website:http://www.humigen.org), invites applicants for a TEAM LEADER position. These positions are open and available immediately. We are interested in candidates dedicated to research in the field of human immunology and immune-mediated diseases. The successful candidate will be expected to develop a strong and independent research program geared toward translational research, with goals directed to biomarker and drug discovery. The Team Leader will join our current research teams which focus on genetic immunology and genomic immunoepidemiology, and take advantage of close ties with the research effort of our sister company, Medical Diagnostic Laboratories (website:http://www.mdlab.com) in pharmacogenomics, antigen discovery, cancer biology, drug design and antimicrobial resistance. Publication and presentation of scientific research as well as the creation of intellectual property are strongly encouraged. Qualified candidates will possess Ph.D. and at least five years of postdoctoral experience. We offer competitive salary, comprehensive benefits including health, life, disability insurance, and 401(k). To apply, please submit a cover letter, curriculum vitae, a two- to three-page research plan and three letters of recommendation.

Informal enquiries can be directed to Dr Grant Gallagher, at: G.Gallagher@Humigen.org.

Please reference IMMUNO with your electronic submission to e-mail: jobs@mdlab.com. HUMIGEN is an Equal Opportunity Employer.

Posted: 3/24/10

NIH- funded postdoctoral or research associate position at SUNY at Farmingdale

Responsibilities include performing research concerning the development and function of monocyte-dendritic cells in normal and abnormal immunity. Aside from having a good foundation in flow cytometry, experience in molecular and cellular experimental approaches such as immunoblot analysis, tissue culture, cell separation, etc., is also desirable. Individuals must possess at least 2 yrs of experience in relevant areas and exhibit independence in research, organizational skills and team work spirit. Salary will be commensurate with experience.

Contact information: Please email cover letter explaining relevant work experience and CV including the names and contact information of three references to Dr. Frances Santiago-Schwarz at santiaf@Farmingdale.edu.

Posted: 3/24/10

Department of Health and Human Services
National Institutes of Health
National Institute of Allergy and Infectious Diseases
Postdoctoral Fellow—Pathogenesis of HIV Infection

The National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research (DIR), Laboratory of Immunoregulation (LIR), HIV-Specific Immunity Section (HSIS) is seeking an outstanding postdoctoral fellow to participate in basic and clinical research in the pathogenesis of HIV infection.

DIR’s mission is to design, initiate, and conduct important basic science and clinical investigations in cutting-edge areas of infectious diseases and allergy/immunology, particularly those of major public health importance. The scientific research program of HSIS is focused on investigating humoral immunity in HIV infection.

There is a growing consensus that effective vaccines for HIV will require a humoral response capable of recognizing diverse isolates. The laboratory has recruited a cohort of patients with a broad and potent neutralizing antibody response to HIV. Sera and cells from these patients are being used in state-of-the-art assays for neutralization, sorting, and single-cell expansion of antigen-specific B cells and for cloning and expression of immunoglobulin genes to better understand the basis of the neutralizing antibody response to HIV.

Applicants should have a Ph.D. and/or M.D. Experience in measuring humoral immune responses in humans or animals and basic molecular biology techniques is desirable. Salary range is commensurate with experience.

Interested candidates may contact Mark Connors, M.D., at mconnors@niaid.nih.gov for additional information about the position. To apply, candidates must submit a curriculum vitae, a bibliography, three letters of reference, a detailed statement of clinical research interests, and reprints of up to three selected publications to National Institute of Allergy and Infectious Diseases, Division of Intramural Research, c/o LIR Office of the Chief, Attn: Dr. Marybeth Daucher (mdaucher@niaid.nih.gov), 10 Center Drive, Room 6A19, Bethesda, MD 20892-1884 by May 31, 2010.

For further information about NIAID and available job opportunities, visit www.niaid.nih.gov/careers/phi10.

HHS, NIH, and NIAID are proud to be Equal Opportunity Employers

Posted: 3/22/10

POSTDOCTORAL POSITIONS – Autoimmunity

Positions are available for Ph.D. or M.D. graduates in the Autoimmunity Center at the Feinstein Institute (Davidson and Zou labs).

Position 1: to study the regulation of B cell development, with a focus on biologic interventions and to investigate mechanisms of target organ damage in SLE. We use mouse models of SLE to study B cell tolerance and employ interventions with biologic therapies to further determine which biologic pathways are optimal targets for therapies. Prior experience in handling of mouse models and/or experience in molecular and cell biology techniques, plus a strong background in immunology are helpful but we will also train qualified candidates. New Ph.D.s welcome. M.D.s wishing to obtain a Ph.D. are eligible to apply for funded positions in the Elmezzi Graduate School of Molecular Medicine (http://www.elmezzigraduateschool.org/).

Position 2: to investigate chemokine receptor CXCR4 signaling and function in hematopoietic stem cells. The project requires hands-on experience in mouse genetics, cell culture, molecular biology and biochemistry.

To apply, e-mail a cover letter, CV, and contact information for three references to:

adavidson1@nshs.edu (position1), Yzou@nshs.edu (position 2)

Posted: 3/15/10

Postdoctoral or Research Associate Position in Molecular Immunology

Positions are available at the Johns Hopkins University School of Medicine to study human cancer immunology. Projects focus on mechanisms of immune regulation and tumor antigen recognition, with an emphasis on clinical translation. Candidates must have a Ph.D. or M.D. degree, a record of scientific accomplishment, and a strong background in immunology and molecular biology. Research Associate applicants must have at least 4 years of significant accomplishment at the postdoctoral level.

Please send CV, statement of research interests, and the names of 3 referees to:

Suzanne L. Topalian, M.D.
Professor, Departments of Surgery and Oncology
Director, Melanoma Program
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (stopali1@jhmi.edu).

Posted: 3/15/10

NIH-funded POSTDOCTORAL POSITION available in the Departments of Biomedical Sciences / Medicine at the Cedars-Sinai Medical Center/UCLA in Los Angeles to study molecular regulation of T cell effector function in the intestinal mucosa.

Current areas of specific interest include the role of a transcriptional repressor in preventing mucosal T cell hyper responsiveness (Nat Immunol. 2006 May;7(5):457-65.; J Exp Med. 2008 Sep 1;205(9):1959-65) and identification of new pathways regulating mucosal T cell function.

Candidates should have a demonstrated record of significant scientific accomplishment at the graduate or postdoctoral level, and a solid background in immunology and/or molecular biology is preferred. Specialty background in mucosal immunology and in vivo mice models preferred but not absolutely required.

To apply send CV and contact list (emails, phone #s and names) of three references to Gislaine A. Martins, Ph.D. (martinsg@cshs.org).

Posted: 3/9/10

Postdoctoral Fellowship in Immunology

A postdoctoral position at the University of Alabama at Birmingham is available to study lymphocyte development and the biology of a novel family of Fc receptor-like (FCRL) molecules. FCRLs possess tyrosine-based regulatory potential and are preferentially expressed by subpopulations of B cells and cytotoxic lymphocytes. Current work in the laboratory focuses on exploring their functional roles in human and mouse models to determine their importance in malignancies and autoimmune disorders.

http://faculty.dom.uab.edu/rsdavis/

A strong background in basic cellular immunobiology is required. Familiarity with molecular biology, flow cytometry, cytotoxicity assays, and biochemistry techniques are highly desirable. Suitable candidates should be able to communicate well verbally and work independently.

Ph.D. and/or M.D. degree is required. Applicants please send curriculum vitae with a description of research interests and names of three references with email addresses to:

Randall S. Davis, M.D.

Associate Professor of Medicine, Microbiology, and

Biochemistry & Molecular Genetics

University of Alabama at Birmingham

1825 University Blvd SHEL412

Birmingham, AL 35294-2182

Email: randall.davis@ccc.uab.edu

Posted: 3/9/10

Postdoctoral Position in Cellular Immunology

NIH-funded Postdoctoral Fellow positions are immediately available in Dr.Booki Min's laboratory in the Department of Immunology at the Cleveland Clinic Lerner Research Institute to investigate T lymphocyte homeostasis in vivo. We are seeking highly motivated, independent and creative individuals with a Ph.D. and/or M.D. degree and a strong interest and training in immunology, and strong verbal and written communication skills. Experimental skills related to FACS, animal handling, adoptive transfer, and T cell activation are strongly desirable. Interested applicants should send their CV, a brief description of research experience, and contact information for three references to Booki Min, minb@ccf.org. Homepage:
http://www.lerner.ccf.org/immuno/min/.

Posted: 2/29/10

Postdoctoral Position, University of Pennsylvania School of Medicine

An NIH-funded postdoctoral fellowship is available for research on the basic mechanisms regulating B cell differentiation.

We are studying several aspects of B cell development and differentiation. These include the transcriptional control of B-lineage commitment and the impact of aging on this process. We are also developing additional projects concerning peripheral B cell development and selection and early plasma cell differentiation. The lab is located on the main medical school campus of the University of Pennsylvania. Additional information can be found by visiting: http://www.med.upenn.edu/immun/allman.shtml

Qualifications: Candidates with research experience in immunology, molecular biology, or related fields are preferred. Applicants must have a Ph.D., D.V.M. or M.D. Work involves experiments with rodents. No previous postdoctoral experience is required, and fewer than four years of postdoctoral experience is required.

To apply, e-mail a cover letter, CV, and contact information for three references to:

David Allman, Ph.D., Associate Professor, Dept. of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th & Hamilton Walk, 230 John Morgan Building, Philadelphia, PA 19104-6082, 215-746-5547 (office), 610-209-5689 (cell), dallman@mail.med.upenn.edu.

Posted: 2/29/10

POSTDOCTORAL POSITIONS - Lymphocyte Signaling Transduction

Positions are available to study the regulation of signal transduction in lymphocytes by protein ubiquitination (Immunity, 21:167, 2004; Mol. Cell, 21:135, 2006; Nature Immunol., 9:245, 2008; PNAS, 106:17847, 2009). We are using mouse models and molecular approaches to study the deficiency of E3 ubiquitin ligases in the development, differentiation, and activation of leukocytes, and their role in autoimmune and inflammatory diseases using mouse models of arthritis, allergic airway inflammation, tumor metastasis, and diabetes. Prior experience in handling of mouse models, and proven records in molecular and cell biology techniques, plus a strong background in immunology are desired.

Please send CV and three names of references to Yun-Cai Liu, Ph.D., Member and Professor, Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Email: yuncail@liai.org; http://www.liai.org/.

Posted: 2/29/10

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Take advantage of this opportunity and sign up for the space ahead of the meeting by contacting Kira Gantt, Ph.D., Manager of Education and Career Services, at kgantt@aai.org.

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